Article

Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T cell responses and promoting allergic inflammation

2023-08-30

Abstract excerpt

<title>Abstract</title> <p> The promoting effect of <italic>FLG</italic> loss-of-function mutations on the development of atopic dermatitis (AD) signifies the role of filaggrin in the formation of a protective skin barrier; <italic>FLG</italic> mutations are also linked to asthma, food allergy and allergic rhinitis despite the absence of the protein in the affected tissues (lungs, intestines, and the majorit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d05ac791-6807-5547-a8fd-e7e39af21ec5
DOI: 10.21203/rs.3.rs-2365588/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T cell responses and promoting allergic inflammationDOI 10.21203/rs.3.rs-2365588/v2Read

Filaggrin and beyondSemantic proximity Read

Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2‐dependent fashionSemantic proximity Read

Could cellular and signaling abnormalities converge to provoke atopic dermatitis?Semantic proximity Read

Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid modelSemantic proximity Read

The multifunctional role of filaggrin in allergic skin disease.Semantic proximity Read

Atopic Dermatitis: The Fate of the FatSemantic proximity Read

Chicken-or-egg question: Which came first, extracellular vesicles or autoimmune diseases?Semantic proximity Read

Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients.Semantic proximity Read

One remarkable molecule: filaggrin.Semantic proximity Read

Loss-of-function mutations within the filaggrin gene and atopic dermatitis.Semantic proximity Read

The role of filaggrin loss-of-function mutations in atopic dermatitis.Semantic proximity Read

Lipid abnormalities in atopic skin are driven by type 2 cytokinesSemantic proximity Read