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Article

Lipid abnormalities in atopic skin are driven by type 2 cytokines

21 Feb 2018

Abstract excerpt

Lipids in the stratum corneum of atopic dermatitis (AD) patients differ substantially in composition from healthy subjects. We hypothesized that hyperactivated type 2 immune response alters AD skin lipid metabolism. We have analyzed stratum corneum lipids from nonlesional and lesional skin of AD subjects and IL-13 skin-specific Tg mice. We also directly examined the effects of IL-4/IL-13 on human keratinocytes in...

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PMID: 29467325
DOI: 10.1172/jci.insight.98006

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