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Article

Could cellular and signaling abnormalities converge to provoke atopic dermatitis?

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG - 1 Nov 2020

Elias Peter M, Wakefield Joan S

Abstract excerpt

Diverse inherited and acquired abnormalities in epidermal structural and enzymatic proteins compromise permeability, barrier function and antimicrobial defense in atopic dermatitis (AD). Though several mutations in filaggrin (FLG) predominate, alterations in other S-100, cornified envelope precursor proteins (hornerin [HRNR], filaggrin 2 [FLG2], SPRR3, mattrin) which regulate lamellar body formation; SPINK5,...

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Source

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Identifiers

PMID: 33048449
DOI: 10.1111/ddg.14232
PMCID: PMC11249044

Genes

FLG
FLG2
HRNR
SPINK5
SPRR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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