Article

Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence.

1994-07-01

Abstract excerpt

Capsule formation plays a significant role in the pathogenicity of Cryptococcus neoformans. To study the molecular basis of capsule synthesis, the capsule-deficient phenotype of a mutant strain was complemented by transformation. A plasmid rescued from the resulting Cap+ transformant complemented a cap59 mutation which was mapped previously by classical recombination analysis. Gene deletion by homologous integrati...

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Literature Corpus work: d04f3c2a-70f8-5d68-b5d4-7125bc9c91f3
DOI: 10.1128/mcb.14.7.4912

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