Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence.

doi:10.1128/mcb.14.7.4912-4919.1994

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Article

Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence.

Molecular and cellular biology - 1 Jul 1994

Chang Y C, Kwon-Chung K J

Abstract excerpt

Capsule formation plays a significant role in the pathogenicity of Cryptococcus neoformans. To study the molecular basis of capsule synthesis, the capsule-deficient phenotype of a mutant strain was complemented by transformation. A plasmid rescued from the resulting Cap+ transformant complemented a cap59 mutation which was mapped previously by classical recombination analysis. Gene deletion by homologous...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Wall
Cryptococcosis
Cryptococcus neoformans
DNA, Fungal
Female
Fungal Proteins
Gene Deletion
Genes, Fungal
Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred Strains

Molecular Sequence Data

Phenotype

Plasmids

Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 8007987
DOI: 10.1128/mcb.14.7.4912-4919.1994
PMCID: PMC358863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8007987-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence.PMID 8007987Read ↗

Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence.Semantic proximity Read ↗

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