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Article

Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence.

Molecular and cellular biology - 1 Jul 1994

Chang Y C, Kwon-Chung K J

Abstract excerpt

Capsule formation plays a significant role in the pathogenicity of Cryptococcus neoformans. To study the molecular basis of capsule synthesis, the capsule-deficient phenotype of a mutant strain was complemented by transformation. A plasmid rescued from the resulting Cap+ transformant complemented a cap59 mutation which was mapped previously by classical recombination analysis. Gene deletion by homologous...

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Identifiers

PMID: 8007987
DOI: 10.1128/mcb.14.7.4912-4919.1994
PMCID: PMC358863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence.PMID 8007987Read ↗

Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence.Semantic proximity Read ↗

Isolation of the Third Capsule-Associated Gene, CAP60 , Required for Virulence in Cryptococcus neoformansSemantic proximity Read ↗

The second capsule gene of cryptococcus neoformans, CAP64, is essential for virulenceSemantic proximity Read ↗

Deletion of the CAP10 gene of Cryptococcus neoformans results in a pleiotropic phenotype with changes in expression of virulence factors.Semantic proximity Read ↗

Complementation of a Capsule Deficient <i>Cryptococcus neoformans</i> with <i>Cap64</i> Restores Virulence in a Murine Lung InfectionSemantic proximity Read ↗

Isolation, Characterization, and Localization of a Capsule-Associated Gene, CAP10 , of Cryptococcus neoformansSemantic proximity Read ↗

Structure and biological activities of acapsular Cryptococcus neoformans 602 complemented with the CAP64 geneSemantic proximity Read ↗

Cas3p belongs to a seven-member family of capsule structure designer proteins.Semantic proximity Read ↗

Production of extracellular polysaccharides by CAP mutants of Cryptococcus neoformans.Semantic proximity Read ↗

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Cryptococcus neoformans CAP59 (or Cap59p) is involved in the extracellular trafficking of capsular glucuronoxylomannan.Semantic proximity Read ↗

The Cryptococcus neoformans Capsule: a Sword and a ShieldSemantic proximity Read ↗

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