Article
Deletion of the CAP10 gene of Cryptococcus neoformans results in a pleiotropic phenotype with changes in expression of virulence factors.
Research in microbiology - 1 Jan 2000
Tefsen Boris, Grijpstra Jan, Ordonez Soledad, Lammers Menno, van Die Irma, de Cock Hans
Abstract excerpt
The human pathogen Cryptococcus neoformans causes meningo-encephalitis. The polysaccharide capsule is an important virulence factor for this yeast-like fungus. Previously, we had shown that disruption of the CAP10 gene, encoding a putative xylosyltransferase, results in mutant cells that lack most of the capsular polysaccharides on the cell surface, but do not show a typical acapsular phenotype. In contrast to...
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