Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Abeta peptide radiopharmaceutical.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Feb 2002

Lee Hwa Jeong, Zhang Yun, Zhu Chunni, Duff Karen, Pardridge William M

Abstract excerpt

Abeta 1-40 is a potential peptide radiopharmaceutical that could be used to image the brain Abeta amyloid of Alzheimer disease in vivo, should this peptide be made transportable through the blood-brain barrier in vivo. The blood-brain barrier transport of [ 125 I]-Abeta 1-40 in a transgenic mouse model was enabled by conjugation to the rat 8D3 monoclonal antibody to the mouse transferrin receptor. The Abeta 1-40...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid
Share to Blood-Brain Barrier

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunotoxins

Share to Indicators and Reagents

Share to Iodine Radioisotopes

Share to Plaque, Amyloid

Share to Receptors, Transferrin

Share to Streptavidin

Source

Identifiers

PMID: 11823720
DOI: 10.1097/00004647-200202000-00010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Abeta peptide radiopharmaceutical.PMID 11823720Read ↗

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody.Semantic proximity Read ↗

Visualization of brain amyloid and microglial activation in mouse models of Alzheimer's disease.Semantic proximity Read ↗

Investigation of the Impact of the H310A FcRn Region Mutation on 89Zr-Immuno-PET Brain Imaging with a BBB-Shuttle Anti‑Amyloid Beta Antibody.Semantic proximity Read ↗

Peripheral and central biodistribution of (111)In-labeled anti-beta-amyloid autoantibodies in a transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Engineering anti-amyloid antibodies with transferrin receptor targeting improves brain biodistribution and mitigates ARIASemantic proximity Read ↗

Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Brain-Penetrating Peptide and Antibody Radioligands for Proof-of-Concept PET Imaging of Fibrin in Alzheimer’s DiseaseSemantic proximity Read ↗

<i>In Vivo</i>Detection of Age- and Disease-Related Increases in Neuroinflammation by<sup>18</sup>F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic MiceSemantic proximity Read ↗

Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse ModelsSemantic proximity Read ↗

Blocking the apolipoprotein E/amyloid-β interaction as a potential therapeutic approach for Alzheimer's diseaseSemantic proximity Read ↗

Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting.Semantic proximity Read ↗

In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.