Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain.

doi:10.1084/jem.20191660

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Article

Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain.

The Journal of experimental medicine - 4 May 2020

Bogie Jeroen F J, Grajchen Elien, Wouters Elien, Corrales Aida Garcia, Dierckx Tess, Vanherle Sam, Mailleux Jo, Gervois Pascal, Wolfs Esther, Dehairs Jonas, Van Broeckhoven Jana, Bowman Andrew P, Lambrichts Ivo, Gustafsson Jan-Åke, Remaley Alan T, Mulder Monique, Swinnen Johannes V, Haidar Mansour, Ellis Shane R, Ntambi James M, Zelcer Noam, Hendriks Jerome J A

Abstract excerpt

Failure of remyelination underlies the progressive nature of demyelinating diseases such as multiple sclerosis. Macrophages and microglia are crucially involved in the formation and repair of demyelinated lesions. Here we show that myelin uptake temporarily skewed these phagocytes toward a disease-resolving phenotype, while sustained intracellular accumulation of myelin induced a lesion-promoting phenotype. This...

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PMID: 32097464
DOI: 10.1084/jem.20191660
PMCID: PMC7201924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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