Article

Strong paracrine effects of SASP from senescence-induced severe early-onset COPD-derived fibroblasts

2023-09-01

Abstract excerpt

<h4>Background</h4> Lung fibroblasts from Severe Early-Onset (SEO-)COPD patients exhibit increased cellular senescence with higher levels of senescence-associated secretory phenotype (SASP) protein secretion. Yet, the impact of senescent fibroblasts, and their SASP, on surrounding fibroblasts in SEO-COPD lungs remains unclear. <h4>Aim</h4> To identify the effect of the SASP secreted by senescent SEO-COPD-derived...

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Literature Corpus work: d00ef86d-d3e4-51f5-8684-f1a588fb4977
DOI: 10.1101/2023.09.01.555721

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