Article
COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins.
Thorax - 1 May 2021
Woldhuis Roy R, Heijink Irene H, van den Berge Maarten, Timens Wim, Oliver Brian G G, de Vries Maaike, Brandsma Corry-Anke
Abstract excerpt
COPD-derived fibroblasts have increased cellular senescence. Senescent cell accumulation can induce tissue dysfunction by their senescence-associated secretory phenotype (SASP). We aimed to determine the SASP of senescent fibroblasts and COPD-derived lung fibroblasts, including severe, early-onset (SEO)-COPD. SASP protein secretion was measured after paraquat-induced senescence in lung fibroblasts using Olink...
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