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Article

Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM.

Cells - 29 Jun 2021

Blokland Kaj E C, Habibie Habibie, Borghuis Theo, Teitsma Greta J, Schuliga Michael, Melgert Barbro N, Knight Darryl A, Brandsma Corry-Anke, Pouwels Simon D, Burgess Janette K

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor survival. Age is a major risk factor, and both alveolar epithelial cells and lung fibroblasts in this disease exhibit features of cellular senescence, a hallmark of ageing. Accumulation of fibrotic extracellular matrix (ECM) is a core feature of IPF and is likely to affect cell function. We hypothesize that aberrant ECM deposition...

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Identifiers

PMID: 34209854
DOI: 10.3390/cells10071628
PMCID: PMC8307656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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