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Article

The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype

24 Jul 2023

Abstract excerpt

Aging is the most prominent nonmodifiable risk factor for various human diseases including Idiopathic pulmonary fibrosis. Aging progressively alters extracellular matrix components and is associated with the accumulation of senescent cells that promote age-related tissue dysfunction. In this review, we will discuss the pathological impact of aging and senescence on lung fibrosis via senescence-associated...

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PMID: 37486065
DOI: 10.1152/ajpcell.00124.2023

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