Article

Cellular Senescence Affects ECM Regulation in COPD Lung Tissue

2023-08-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Higher levels of cellular senescence have been demonstrated in COPD patients, including severe early-onset (SEO)-COPD. Recently, we demonstrated that senescence induces extracellular matrix (ECM) dysregulation in lung fibroblasts. However, this in vitro observation has not been demonstrated in vivo yet. Therefore, we investigated whether cellular senescence can contribut...

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Literature Corpus work: 1802d859-8019-56f5-b6a1-1e62b5f7b50e
DOI: 10.1101/2023.08.02.551614

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