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Article

Understanding the diversity of genetic outcomes from CRISPR-Cas generated homology-directed repair.

Communications biology - 1 Jan 2019

Sansbury Brett M, Hewes Amanda M, Kmiec Eric B

Abstract excerpt

As CRISPR-Cas systems advance toward clinical application, it is essential to identify all the outcomes of gene-editing activity in human cells. Reports highlighting the remarkable success of homology-directed repair (HDR) in the treatment of inherited diseases may inadvertently underreport the collateral activity of this remarkable technology. We are utilizing an in vitro gene-editing system in which a...

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Identifiers

PMID: 31840103
DOI: 10.1038/s42003-019-0705-y
PMCID: PMC6898364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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