Article

Permutation-calibrated stability discovery under p >> n : A leak-controlled Machine Learning framework identifies candidate proteomics panels in antiseizure medications-related side effects

2026-02-26

Abstract excerpt

We investigated whether the plasma proteome distinguishes people with epilepsy who report central nervous system (CNS) side effects from antiseizure medications (ASMs) from those who do not. In 161 patients profiled using proximity extension assay-based proteomics Neurology and Inflammation panels (∼1,447 proteins), we applied an ensemble leak-controlled machine-learning (ML) workflow based on LASSO (linear) and r...

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Literature Corpus work: d00e2795-6919-5d2b-ab87-492ea7040f96
DOI: 10.64898/2026.02.24.707860

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