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Article

Drug repositioning in epilepsy reveals novel antiseizure candidates

11 Dec 2018

Abstract excerpt

Objective: Epilepsy treatment falls short in ~30% of cases. A better understanding of epilepsy pathophysiology can guide rational drug development in this difficult to treat condition. We tested a low-cost, drug-repositioning strategy to identify candidate epilepsy drugs that are already FDA-approved and might be immediately tested in epilepsy patients who require new therapies. Methods: Biopsies of spiking and...

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PMID: 30847362
DOI: 10.1002/acn3.703

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