Article

Forecasting off-target drug toxicity using proteomic and genetic data: insights from Torcetrapib

2025-12-04

Abstract excerpt

In the development of new drugs, one of the leading causes of late-stage failures are off-target adverse effects, but they are difficult to predict before expensive large-scale clinical trials. Proteomic changes observed in randomized controlled trials (RCTs) and Mendelian randomization estimates of the effects of these changes can provide valuable evidence about the likely effects of drugs on health outcomes. We...

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Literature Corpus work: bd403334-793c-5d6a-be28-ae2c6c3aa3f4
DOI: 10.64898/2025.12.03.25341213

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