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Article

Potential causal link between antiseizure medication targets and cognitive function: A mendelian randomization study.

Progress in neuro-psychopharmacology & biological psychiatry - 30 Aug 2025

Zhu Kun, Yu Jian, Liu Junyan, Liu Yingzi, Cao Danfeng, Zhou Honghao, Zeng Feiyue, Liu Zhaoqian, Mao Xiaoyuan

Abstract excerpt

A common strategy for treating epilepsy is the use of antiseizure medications (ASMs). However, ASMs usually raise concerns about accompanying side effects on the cognitive function of patients. Understanding the causal relationship between ASMs targets and cognitive function is crucial for developing therapeutic strategies that mitigate cognitive side effects while effectively managing seizures. This study aimed...

Read the complete abstract on PubMed

Topics

Humans
Mendelian Randomization Analysis
Anticonvulsants
Genome-Wide Association Study
Cognition

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Epilepsy

Quantitative Trait Loci

Source

Identifiers

PMID: 40738297
DOI: 10.1016/j.pnpbp.2025.111463

Genes

CA13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Oct 2026.

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