Back to search

Article

Potential Targets for Epilepsy Treatment: An Integrated Study Based on Multi-omics, Mendelian Randomization, Immune Infiltration Assessment, and Machine Learning

2024-12-19

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Epilepsy is a severe neurological disease. Exploring the intrinsic mechanisms of the onset and development of epilepsy, and seeking new therapeutic targets and diagnostic markers, remain very important for epilepsy research. <bold>Methods: </bold>Two independent epilepsy microarray datasets from the GEO database were used to identify differentially expressed gen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ccadb3eb-d540-51cd-beb8-83e6f7e2a036
DOI
10.21203/rs.3.rs-5656048/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Potential Targets for Epilepsy Treatment: An Integrated Study Based on Multi-omics, Mendelian Randomization, Immune Infiltration Assessment, and Machine LearningDOI 10.21203/rs.3.rs-5656048/v1
Integrated Mendelian Randomization and Single‐Cell Transcriptomics Analysis Identifies Critical Blood Biomarkers and Potential Mechanisms in EpilepsySemantic proximity
Identification and verification of anoikis-related genes immune infiltration characterization based on machine learning for epilepsySemantic proximity
Causal relationship between immune cells and epilepsy mediated by metabolites analyzed through Mendelian randomization.Semantic proximity
Naive CD8br T Cell Affects Epilepsy through Partial Sphingomyelin Mediation: A Mendelian Randomization StudySemantic proximity
Relationship between inflammation/immunity and epilepsy: A multi-omics mendelian randomization study integrating GWAS, eQTL, and mQTL data.Semantic proximity
The association between immune cells and epilepsy：Evidence from Mendelian randomization study and meta-analysisSemantic proximity
Cerebrospinal fluid metabolites and brain imaging in epilepsy subtypes: Mendelian randomization and multi-omics analysis.Semantic proximity
Characterization of Immune-Related Genes and Immune Infiltration Features in Epilepsy by Multi-Transcriptome DataSemantic proximity
Exploring correlations between immune cell phenotypes and the risk of epilepsy: A bidirectional Mendelian randomization study.Semantic proximity
Insight on the hub gene associated signatures and potential therapeutic agents in epilepsy and gliomaSemantic proximity
Unraveling Epilepsy Biomarkers through Single-Cell Sequencing and GEO Data Integration: A Focus on Parthanatos PathwaySemantic proximity
Unraveling the links between circulating bioactive factors and epilepsy: A bidirectional Mendelian randomization study.Semantic proximity
Select a neighboring publication to make it the new centre.