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Article

mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 May 2018

Norrmén Camilla, Figlia Gianluca, Pfistner Patrick, Pereira Jorge A, Bachofner Sven, Suter Ueli

Abstract excerpt

Schwann cells (SCs) are endowed with a remarkable plasticity. When peripheral nerves are injured, SCs dedifferentiate and acquire new functions to coordinate nerve repair as so-called repair SCs. Subsequently, SCs redifferentiate to remyelinate regenerated axons. Given the similarities between SC dedifferentiation/redifferentiation in injured nerves and in demyelinating neuropathies, elucidating the signals...

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Identifiers

PMID: 29695414
DOI: 10.1523/JNEUROSCI.3619-17.2018
PMCID: PMC5956991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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