Article
Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity.
The Journal of cell biology - 1 Feb 2017
Mindos Thomas, Dun Xin-Peng, North Katherine, Doddrell Robin D S, Schulz Alexander, Edwards Philip, Russell James, Gray Bethany, Roberts Sheridan L, Shivane Aditya, Mortimer Georgina, Pirie Melissa, Zhang Nailing, Pan Duojia, Morrison Helen, Parkinson David B
Abstract excerpt
Loss of the Merlin tumor suppressor and activation of the Hippo signaling pathway play major roles in the control of cell proliferation and tumorigenesis. We have identified completely novel roles for Merlin and the Hippo pathway effector Yes-associated protein (YAP) in the control of Schwann cell (SC) plasticity and peripheral nerve repair after injury. Injury to the peripheral nervous system (PNS) causes a...
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