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Article

Valvulogenesis: the moving target

14 Jun 2007

Abstract excerpt

Valvulogenesis is an extremely complex process by which a fragile gelatinous matrix is populated and remodelled during embryonic development into thin fibrous leaflets capable of maintaining unidirectional flow over a lifetime. This process occurs during exposure to constantly changing haemodynamic forces, with a success rate of approximately 99%. Defective valvulogenesis results in impaired cardiac function and...

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Identifiers

PMID: 17569640
DOI: 10.1098/rstb.2007.2130

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