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Feeder-free generation and characterization of endocardial and cardiac valve cells from human pluripotent stem cells

30 Nov 2023

Abstract excerpt

Valvular heart disease presents a significant health burden, yet advancements in valve biology and therapeutics have been hindered by the lack of accessibility to human valve cells. In this study, we have developed a scalable and feeder-free method to differentiate human induced pluripotent stem cells (iPSCs) into endocardial cells, which are transcriptionally and phenotypically distinct from vascular endothelial...

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PMID: 38170020
DOI: 10.1016/j.isci.2023.108599

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