Article

Feeder-Free Generation of Endocardial and Cardiac Valve Cells from Human Pluripotent Stem Cells

2023-03-03

Abstract excerpt

<h4>Summary</h4> Valvular heart disease presents a significant health burden, yet advancements in valve biology and novel therapeutics have been hindered by the lack of accessibility to human valve cells. In this study, we have developed a scalable and feeder-free method to differentiate human induced pluripotent stem cells (iPSCs) into endocardial cells. Importantly, we show that these endocardial cells are tran...

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Literature Corpus work: 112ee2cd-612e-57aa-ada2-fe294d06cac9
DOI: 10.1101/2023.03.03.530824

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