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Induced pluripotent stem cells for cardiovascular disease: from product-focused disease modeling to process-focused disease discovery.

Regenerative medicine - 1 Jan 2015

Campbell Katherine A, Terzic Andre, Nelson Timothy J

Abstract excerpt

Induced pluripotent stem (iPS) cell technology offers an unprecedented opportunity to study patient-specific disease. This biotechnology platform enables recapitulation of individualized disease signatures in a dish through differentiation of patient-derived iPS cells. Beyond disease modeling, the in vitro process of differentiation toward genuine patient tissue offers a blueprint to inform disease etiology and...

Topics

Animals
Biotechnology
Cardiovascular Diseases
Cell Differentiation
Cellular Reprogramming
Disease Models, Animal
Humans
Induced Pluripotent Stem Cells
Phenotype
Regenerative Medicine
Tissue Engineering

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Identifiers

PMID: 26439809
DOI: 10.2217/rme.15.41
PMCID: PMC4747237

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