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Adipose tissue macrophage heterogeneity in the single-cell genomics era

1 Feb 2024

Abstract excerpt

It is now well-accepted that obesity-induced inflammation plays an important role in the development of insulin resistance and type 2 diabetes. A key source of the inflammation is the murine epididymal and human visceral adipose tissue. The current paradigm is that obesity activates multiple proinflammatory immune cell types in adipose tissue, including adipose-tissue macrophages (ATMs), T Helper 1 (Th1) T cells,...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 38354858
DOI: 10.1016/j.mocell.2024.100031

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