Back to search

Article

Lipoproteome screening of the Lyme disease agent identifies novel inhibitors of antibody-mediated complement killing

2021-09-23

Abstract excerpt

Spirochetal pathogens such as the causative agent of Lyme disease, Borrelia burgdorferi sensu lato, encode an abundance of lipoproteins; however, due in part to their evolutionary distance from more well-studied bacteria such as Proteobacteria and Firmicutes, very few spirochetal lipoproteins have assigned functions. Indeed, B. burgdorferi devotes almost 8% of its genome to lipoprotein genes and interacts with i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3adc400c-257b-5873-9d4d-9ecfe8bdc784
DOI
10.1101/2021.09.23.461563
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Lipoproteome screening of the Lyme disease agent identifies novel inhibitors of antibody-mediated complement killingDOI 10.1101/2021.09.23.461563
Borrelia miyamotoi FbpA and FbpB Are Immunomodulatory Outer Surface Lipoproteins With Distinct Structures and FunctionsSemantic proximity
Comprehensive Spatial Analysis of the Borrelia burgdorferi Lipoproteome Reveals a Compartmentalization Bias toward the Bacterial SurfaceSemantic proximity
Multifunctional and Redundant Roles of Borrelia burgdorferi Outer Surface Proteins in Tissue Adhesion, Colonization, and Complement EvasionSemantic proximity
Heterologous Surface Display Reveals Conserved Complement Inhibition and Functional Diversification of <i>Borrelia burgdorferi</i> Elp ProteinsSemantic proximity
Lipid hijacking: A unifying theme in vector-borne diseasesSemantic proximity
Lipoproteins of Bacterial PathogensSemantic proximity
Complement therapeutic Factor H-IgG proteins as pre-exposure prophylaxes against Lyme borreliae infectionsSemantic proximity
Contribution of the Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (ErpC) to Complement Resistance of<i>Borrelia burgdorferi</i>Semantic proximity
Role of Dual Specificity Phosphatase 1 (DUSP1) in influencing inflammatory pathways in macrophages modulated by <i>Borrelia burgdorferi</i> lipoproteinsSemantic proximity
That's my story, and I'm sticking to it—an update on B. burgdorferi adhesinsSemantic proximity
A Borrelia burgdorferi LptD homolog is required for flipping of surface lipoproteins through the spirochetal outer membraneSemantic proximity
Complement regulator-acquiring surface proteins of Borrelia burgdorferi: Structure, function and regulation of gene expressionSemantic proximity
Select a neighboring publication to make it the new centre.