Article

A high affinity human monoclonal antibody against Pfs230 binds multiple parasite stages and blocks oocyst formation in mosquitoes

2020-09-25

Abstract excerpt

<h4>ABSTRACT</h4> Malaria elimination requires tools that interrupt parasite transmission. Here, we characterized B cell receptor responses among Malian adults vaccinated against the first domain of the cysteine-rich 230kDa gamete surface protein Pfs230 1–3 to neutralize sexual stage P. falciparum parasites and halt their further spread. We generated nine Pfs230 human monoclonal antibodies (mAbs). One mAb poten...

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Literature Corpus work: f30ea9cb-5e4f-5092-aad5-3996c6b3318d
DOI: 10.1101/2020.09.25.313478

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