Article

Toti: an integrated multi-omics database to decipher the epigenetic regulation of gene expression in totipotent stem cells

2025-01-25

Abstract excerpt

Totipotent cells (TSCs), the origin of mammalian life and foundation to early mammalian embryogenesis, are characterized by the highest differentiation capacity and extensive developmental potential. However, none of the existing embryonic databases have provided epigenetic and transcriptomic resources on totipotency, greatly limiting our understanding of the mechanisms governing the establishment and exit of toti...

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Literature Corpus work: cfc6d734-0e6b-59b9-83ac-69fa98fc8c6e
DOI: 10.1101/2025.01.24.634821

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