Article

Integrated multi-omics analyses reveal the pro-inflammatory and pro-fibrotic pulmonary macrophage subcluster in silicosis

2024-02-21

Abstract excerpt

<h4>Background</h4> Silicosis is a lethal occupational disease caused by long-term exposure to respirable silica dust. Pulmonary macrophages play a crucial role in mediating the initiation of silicosis. However, the phenotypic and functional heterogeneities of pulmonary macrophages in silicosis have not been well-studied. <h4>Methods</h4> The silicosis mouse model was established by intratracheal administration...

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Literature Corpus work: 155be9a3-7bee-5543-9897-0fffa1e2286a
DOI: 10.1101/2024.02.16.580775

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