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Integrated multi-omics analyses reveal the pro-inflammatory and pro-fibrotic pulmonary macrophage subcluster in silicosis

23 Aug 2024

Abstract excerpt

Silicosis is a lethal occupational disease caused by long-term exposure to respirable silica dust. Pulmonary macrophages play a crucial role in mediating the initiation of silicosis. However, the phenotypic and functional heterogeneities of pulmonary macrophages in silicosis have not been well-studied. The silicosis mouse model was established by intratracheal administration of silica suspension. Bronchoalveolar...

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PMID: 39181076
DOI: 10.1016/j.ecoenv.2024.116899

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