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Article

Multi-omics and multi-stages integration identified a novel variant associated with silicosis risk.

Archives of toxicology - 1 Sept 2024

Jin Chunmeng, Tao Xiaobo, Zhang Wendi, Xu Huiwen, Wu Yutong, Chen Qiong, Li Siqi, Ning Anhui, Wang Wei, Wu Qiuyun, Chu Minjie

Abstract excerpt

Assessing the association between candidate single-nucleotide polymorphisms (SNPs) identified by multi-omics approaches and susceptibility to silicosis. RNA-seq analysis was performed to screen the differentially expressed mRNAs in the fibrotic lung tissues of mice exposed to silica particles. Following this, we integrated the SNPs located in the above human homologenes with the silicosis-related genome-wide...

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PMID: 38811393
DOI: 10.1007/s00204-024-03795-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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