Article

GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis

2022-03-23

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Fibroblasts have important roles in the synthesis and remodeling of extracellular matrix (ECM) proteins during pulmonary fibrosis. However, the spatiotemporal distribution of heterogeneous fibroblasts during disease progression remains unknown.<bold>Results: </bold>In the current study, silica was used to generate a mouse model of pathological changes in the lun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2caca9e6-edef-5825-a56c-4d1c4ae31ad5
DOI: 10.21203/rs.3.rs-1394015/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosisDOI 10.21203/rs.3.rs-1394015/v1Read

GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosisSemantic proximity Read

PPP2R3A Affects the Function and Mechanism of Heterogeneous Fibroblasts in Pulmonary FibrosisSemantic proximity Read

Integrated multi-omics analyses reveal the pro-inflammatory and pro-fibrotic pulmonary macrophage subcluster in silicosisSemantic proximity Read

Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosisSemantic proximity Read

Integrated multi-omics analyses reveal the pro-inflammatory and pro-fibrotic pulmonary macrophage subcluster in silicosisSemantic proximity Read

Macrophage-derived GPNMB Trapped by Fibrotic Extracellular Matrix Promotes Pulmonary FibrosisSemantic proximity Read

Comparative RNA‐Seq transcriptome analysis on silica induced pulmonary inflammation and fibrosis in mice silicosis modelSemantic proximity Read

Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosisSemantic proximity Read

Translational mapping of spatially resolved transcriptomes in human and mouse pulmonary fibrosisSemantic proximity Read

Comparative Transcriptome Analyses Reveal a Transcriptional Landscape of Human Silicosis Lungs and Provide Potential Strategies for Silicosis TreatmentSemantic proximity Read

IL33-regulated NPM1 promotes fibroblast-to-myofibroblast transition via ERK/AP-1 signaling in silica-induced pulmonary fibrosisSemantic proximity Read

Genome-wide DNA methylation analysis in lung fibroblasts co-cultured with silica-exposed alveolar macrophagesSemantic proximity Read