Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease

14 Jan 2010

Abstract excerpt

BACKGROUND: The low-density lipoprotein receptor related protein 1 (LRP1) has been implicated in Alzheimer's disease (AD) but its signalling has not been fully evaluated. There is good evidence that the cytoplasmic domain of LRP1 is involved in protein-protein interactions, important in the cell biology of LRP1. RESULTS: We carried out three yeast two-hybrid screens to identify proteins that interact with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Protein Tyrosine Phosphatases
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20205790
DOI: 10.1186/1750-1326-5-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's diseasePMID 20205790Read ↗

Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer’s Disease-related endosomal and synaptic dysfunction with cholinergic neurodegenerationSemantic proximity Read ↗

Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegenerationSemantic proximity Read ↗

LDL Receptor–Related Protein-1Semantic proximity Read ↗

Endogenous Protein-Protein Interaction Network of the NPC Cholesterol Transporter 1 in the Cerebral Cortex.Semantic proximity Read ↗

Interactome mapping reveals a role for LRP10 in autophagy and NDFIP1-mediated α-synuclein secretionSemantic proximity Read ↗

NDRG2: a novel Alzheimer's disease associated proteinSemantic proximity Read ↗

The Ligand Preference of LRP1 is Regulated by O-glycansSemantic proximity Read ↗

Proteomic characterization of the Alzheimer’s disease risk factor BIN1 interactomeSemantic proximity Read ↗

Cell type-specific functions of Alzheimer's disease endocytic risk genesSemantic proximity Read ↗

Alzheimer’s disease-associated Presenilin 2 N141I mutation impairs neuronal lipid homeostasis and mitochondrial dynamics through selective downregulation of the Golgi exchange factor <i>Gbf1</i>Semantic proximity Read ↗

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s diseaseSemantic proximity Read ↗

Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.