Article

SARS-CoV-2 Omicron Variant: ACE2 Binding, Cryo-EM Structure of Spike Protein-ACE2 Complex and Antibody Evasion

2021-12-21

Abstract excerpt

The newly reported Omicron variant is poised to replace Delta as the most rapidly spread SARS-CoV-2 variant across the world. Cryo-EM structural analysis of the Omicron variant spike protein in complex with human ACE2 reveals new salt bridges and hydrogen bonds formed by mutated residues R493, S496 and R498 in the RBD with ACE2. These interactions appear to compensate for other Omicron mutations such as K417N know...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: baf643fd-eadb-5413-bc2a-3ee2dde3cf43
DOI: 10.1101/2021.12.19.473380

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 Omicron Variant: ACE2 Binding, Cryo-EM Structure of Spike Protein-ACE2 Complex and Antibody EvasionDOI 10.1101/2021.12.19.473380Read

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex.Semantic proximity Read

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variantSemantic proximity Read

Structures of Omicron spike complexes and implications for neutralizing antibody developmentSemantic proximity Read

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody: mechanisms for the high infectivity, immune evasion and antibody drug discoverySemantic proximity Read

Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 OmicronSemantic proximity Read

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagementSemantic proximity Read

Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.Semantic proximity Read

Omicron Spike protein has a positive electrostatic surface that promotes ACE2 recognition and antibody escapeSemantic proximity Read

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement.Semantic proximity Read

Omicron Spike Protein Has a Positive Electrostatic Surface That Promotes ACE2 Recognition and Antibody EscapeSemantic proximity Read

Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interactionSemantic proximity Read

Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike proteinSemantic proximity Read