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SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex.

Science (New York, N.Y.) - 18 Feb 2022

Mannar Dhiraj, Saville James W, Zhu Xing, Srivastava Shanti S, Berezuk Alison M, Tuttle Katharine S, Marquez Ana Citlali, Sekirov Inna, Subramaniam Sriram

Abstract excerpt

The newly reported Omicron variant is poised to replace Delta as the most prevalent SARS-CoV-2 variant across the world. Cryo-EM structural analysis of the Omicron variant spike protein in complex with human ACE2 reveals new salt bridges and hydrogen bonds formed by mutated residues R493, S496 and R498 in the RBD with ACE2. These interactions appear to compensate for other Omicron mutations such as K417N known to...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35050643
DOI: 10.1126/science.abn7760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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