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Article

The global phylogeography of rapidly expanding multidrug resistant Ural lineage 4.2 Mycobacterium tuberculosis.

Nature communications - 31 Mar 2026

Chitwood Melanie H, Rancu Isabel, Song Yexuan, Potter Barney I, Chew Yi Ting, Ciobanu Nelly, Crudu Valeriu, Colijn Caroline, Cohen Ted, Sobkowiak Benjamin

Abstract excerpt

Multidrug resistant tuberculosis (MDR-TB) epidemics are sustained by transmission of reproductively fit MDR M. tuberculosis (Mtb) strains. We search a large publicly available dataset of ~200,000 Mtb whole genome sequences to identify strains related to a highly successful MDR clade circulating in Moldova belonging to lineage 4.2.1/Ural. We characterize a clade of 1604 drug-resistant Mtb sequences harboring...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41917024
DOI: 10.1038/s41467-026-71193-6
PMCID: PMC13201588

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