Article

IMPA2 Ameliorates High-Fat Diet-Induced Obesity by Enhancing Adaptive Thermogenesis in a Ca2+-activated Mitochondrial Biogenesis Pathway

2025-06-21

Abstract excerpt

<title>Abstract</title> <p> The identification of thermogenic adipocytes in humans proves that enhanced adaptive thermogenesis may help mitigate obesity. Although some evidence suggests a role for IMPA2 in cellular metabolism, its specific impact on obesity and the underlying mechanisms remain underexplored. High-fat-diet (HFD)-induced obese mice were employed as experimental models. Cold exposure (4°C) or admin...

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Literature Corpus work: cf40073d-b608-5eaf-8809-dede9dec91d2
DOI: 10.21203/rs.3.rs-6845207/v1

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