Article

A role of extracellular vesicle-mediated inter-organ communication in obesity-related arrhythmia

2025-09-17

Abstract excerpt

<h4>ABSTRACT</h4> Obesity contributes to the risk of cardiac arrhythmias, but the exact mechanism remains unclear. Here, we show visceral adipose tissue-derived extracellular vesicles (VAT EVs) from individuals with obesity prolong action potential duration (APD) and impair calcium handling in stem cell-derived cardiomyocytes, in addition to activating fibroblasts and macrophages towards a pro-fibrotic/inflammato...

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Literature Corpus work: 0f5a0d7c-83d1-5e24-95c3-6df1bd05b81b
DOI: 10.1101/2025.09.13.676027

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