Article

HIF1α controls adipose tissue growth through metabolic rechanneling

2024-05-30

Abstract excerpt

Excessive expansion of white adipose tissue occurs when energy intake exceeds demand. It creates a state of relative hypoxia that is directly linked to activation of the hypoxia-inducible factor (HIF) in obese human subjects and mouse models of obesity. Whether HIF1α function is important for the development of basal adiposity and diet-induced obesity remains unclear. In the present study, we genetically ablated H...

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Literature Corpus work: c72441a2-7866-565b-beb1-86c13884012b
DOI: 10.1101/2024.05.28.596336

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