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Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning

7 Mar 2017

Abstract excerpt

Obesity results from increased energy intake or defects in energy expenditure. Brown adipose tissue (BAT) is specialized for energy expenditure, a process called adaptive thermogenesis. Peroxisome proliferator–activated receptor γ coactivator 1α (PGC1α) controls BAT-mediated thermogenesis by regulating the expression of Ucp1. Inhibitor of differentiation 1 (Id1) is a helix-loop-helix transcription factor that...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 28270523
DOI: 10.2337/db16-1079

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