Article

Experimental characterisation of <i>de novo</i> proteins and their unevolved random-sequence counterparts

2022-01-17

Abstract excerpt

De novo gene emergence provides a route for new proteins to be formed from previously non-coding DNA. Proteins born in this way are considered random sequences, and typically assumed to lack defined structure. While it remains unclear how likely a de novo protein is to assume a soluble and stable tertiary structure, intersecting evidence from random-sequence and de novo -designed proteins suggests that native-li...

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Literature Corpus work: cf2e3c2e-eed1-5bb2-94bc-4ce5f0dd4b1a
DOI: 10.1101/2022.01.14.476368

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