Article
Terminal sequence importance of de novo proteins from binary-patterned library: stable artificial proteins with 11- or 12-amino acid alphabet.
Protein and peptide letters - 1 Jun 2012
Okura Hiromichi, Takahashi Tsuyoshi, Mihara Hisakazu
Abstract excerpt
Successful approaches of de novo protein design suggest a great potential to create novel structural folds and to understand natural rules of protein folding. For these purposes, smaller and simpler de novo proteins have been developed. Here, we constructed smaller proteins by removing the terminal sequences from stable de novo vTAJ proteins and compared stabilities between mutant and original proteins. vTAJ...
Topics
- Amino Acid Sequence
- Amino Acids
- Anilino Naphthalenesulfonates
- Hydrogen-Ion Concentration
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Denaturation
- Protein Engineering
- Protein Folding
- Protein Stability
- Protein Structure, Secondary
- Proteins
- Sequence Alignment