Article

Protein structure shapes natural genetic variation and <i>de novo</i> adaptation

2025-12-22

Abstract excerpt

Protein structural context strongly influences the functional outcomes of mutations, but exploiting this intuition to interpret the consequences of natural variants has been limited by the paucity of structural information. Here, we show that simple molecular heuristics based on predicted protein structures–solvent accessibility and the local complexity of the protein fold–are strong predictors of protein-coding v...

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Literature Corpus work: 11f1b8ab-a8f6-5f84-81ee-c117f791666d
DOI: 10.64898/2025.12.19.695599

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