Article

<i>De Novo</i> Protein Fold Design Through Sequence-Independent Fragment Assembly Simulations

2022-05-17

Abstract excerpt

De novo protein design generally consists of two steps, including structure and sequence design. However, many protein design studies have focused on sequence design with scaffolds adapted from native structures in the PDB, which renders novel areas of protein structure and function space unexplored. Here we developed FoldDesign to create novel protein folds from specific secondary structure (SS) assignments throu...

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Literature Corpus work: dae91424-168d-5304-a18e-6fb5d5c31d12
DOI: 10.1101/2022.05.16.492148

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