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Article

APOE4 and doxorubicin impair inhibitory interneuron function and homeostatic regulation in the entorhinal cortex.

PloS one - 1 Jan 2026

Luo Nancy, Pandit Harshul, Kalra Shreya, Tran Erin, Mandelblatt Jeanne, Vicini Stefano, Rebeck G William

Abstract excerpt

APOE4 is a risk factor for several disease states associated with cognitive impairment, including Alzheimer's disease and cancer-chemotherapy induced cognitive impairment. Using mouse knock-in models of human APOE alleles, we examined the effects of APOE genotype and chemotherapy on the ex vivo electrophysiological characteristics of excitatory and inhibitory neurons in the entorhinal cortex (EC). We found that...

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Identifiers

PMID: 41886471
DOI: 10.1371/journal.pone.0343276
PMCID: PMC13020844

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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