Interaction Between Odor Identification Deficit and APOE4 Predicts 6-Year Cognitive Decline in Elderly Individuals.

doi:10.1007/s10519-019-09980-9

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Article

Interaction Between Odor Identification Deficit and APOE4 Predicts 6-Year Cognitive Decline in Elderly Individuals.

Behavior genetics - 1 Jan 2020

Olofsson Jonas K, Larsson Maria, Roa Catalina, Wilson Donald A, Jonsson Laukka Erika

Abstract excerpt

Olfactory identification impairment might indicate future cognitive decline in elderly individuals. An unresolved question is to what extent this effect is dependent on the ApoE-ε4, a genotype associated with risk of Alzheimer's Disease (AD). Given the current concern about reproducibility in empirical research, we assessed this issue in a large sample (n = 1637) of older adults (60 - 96 years) from the...

Topics

Aged
Aged, 80 and over
Aging
Alleles
Apolipoprotein E4
Apolipoproteins E
Cognition
Cognitive Dysfunction
Female
Gene Frequency
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Neuropsychological Tests

Odorants

Olfactory Perception

Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 31760549
DOI: 10.1007/s10519-019-09980-9
PMCID: PMC6941999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-31760549-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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