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Article

Dynamics of protein noise can distinguish between alternate sources of gene-expression variability.

Molecular systems biology - 1 Jan 2012

Singh Abhyudai, Razooky Brandon S, Dar Roy D, Weinberger Leor S

Abstract excerpt

Within individual cells, two molecular processes have been implicated as sources of noise in gene expression: (i) Poisson fluctuations in mRNA abundance arising from random birth and death of individual mRNA transcripts or (ii) promoter fluctuations arising from stochastic promoter transitions between different transcriptional states. Steady-state measurements of variance in protein levels are insufficient to...

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PMID: 22929617
DOI: 10.1038/msb.2012.38
PMCID: PMC3435505

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