Article

Loss of the first β-strand of human prion protein generates an aggregation-competent partially “open” form

2022-09-21

Abstract excerpt

Prion diseases, a group of incurable, lethal neurodegenerative disorders of mammals including humans, are caused by prions, assemblies of misfolded host prion protein (PrP). The pathway of PrP misfolding is still unclear, though previous data indicate the presence of a structural core in cellular PrP (PrP C ), whose cooperative unfolding presents a substantial energy barrier on the path to prion formation. PrP is...

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Literature Corpus work: 5a3e60bd-ee9f-5f23-853a-39a318f06ac3
DOI: 10.1101/2022.09.20.508729

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