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Article

Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein.

The Journal of biological chemistry - 7 Feb 2003

Nunziante Max, Gilch Sabine, Schätzl Hermann M

Abstract excerpt

Aberrant metabolism and conformational alterations of the cellular prion protein (PrP(c)) are the underlying causes of transmissible spongiform encephalopathies in humans and animals. In cells, PrP(c) is modified post-translationally and transported along the secretory pathway to the plasma membrane, where it is attached to the cell surface by a glycosylphosphatidylinositol anchor. In surface biotinylation assays...

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Identifiers

PMID: 12431994
DOI: 10.1074/jbc.M206313200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein.PMID 12431994Read ↗

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